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What is aspartame, the additive in your diet cola, which the WHO may declare as ‘possibly carcinogenic’?

 

The cancer research arm of the World Health Organisation (WHO) will list the popular sugar substitute aspartame as “possibly carcinogenic to humans”, the news agency Reuters reported on Thursday (June 29). The listing by the International Agency for Research on Cancer (IARC) is likely next month, the Reuters report said, quoting unnamed sources.

Aspartame is one of the world’s most common artificial sweeteners and is used in a wide range of diet soft drinks, sugar-free chewing gum, sugar-free ice cream, sugar-free breakfast cereals, etc.

A number of studies have repeatedly said that aspartame does not pose a risk for cancer. The listing by WHO, if it comes, will break from those earlier findings, “pitting it against the food industry and regulators”, the Reuters report said.

What is this assessment by the WHO?

Two different WHO groups — IARC and the Joint Organization Expert Committee on Food Additives, or JECFA — are currently reviewing the safety of aspartame.

The IARC concluded a meeting in France last week, and JECFA was scheduled to meet from June 27 to July 6 to update its risk assessment of aspartame, including reviewing how much can be safely consumed, The Washington Post reported on June 22.

The result of both evaluations would be announced on July 14, The Post’s report said, and noted that “many in the nutrition world [were] predicting the WHO will convey new concerns about the sweetener”.

The Reuters report published on June 29 said the IARC ruling had been “finalised earlier this month”, based on a review of all published evidence.

It said that the IARC assessment “does not take into account how much of a product a person can safely consume”, and that “this advice for individuals comes from…[the] JECFA, alongside determinations from national regulators”.
And what exactly is aspartame?

Chemically, aspartame is a methyl ester of the dipeptide of two natural amino acids, L-aspartic acid and L-phenylalanine. It was discovered by James M Schlatter, a chemist at the American pharmaceutical company G D Searle & Co. (which is now a subsidiary of Pfizer) in 1965, apparently by accident, when, while researching an anti-ulcer drug, he happened to lick his finger and detected a sweet taste.

According to the US Food and Drug Administration (FDA), aspartame is about 200 times sweeter than table sugar — which makes aspartame far less sweet than other artificial sweeteners like advantame and neotame, but even then, 1 gram of aspartame has the sweetness intensity of roughly 2 teaspoons (about 8 g) of sugar.

According to the US Food and Drug Administration (FDA), aspartame is about 200 times sweeter than table sugar According to the US Food and Drug Administration (FDA), aspartame is about 200 times sweeter than table sugar.

Aspartame is preferred by people trying to cut calories or lose weight, or by diabetics, because while 2 teaspoons (8 g) of sugar provides about 32 kcals of energy, 1 g of aspartame is only 4 kcals.

It is often argued that a 12 fl oz (about 350 ml) can of regular cola contains about 10 teaspoonfuls of sugar, while the same quantity of diet cola containing aspartame has only 7 kcals. Indeed, cans/ bottles of diet fizzy drinks often say “zero sugar” or “zero calories” on the packaging.

Aspartame is present in several brands of artificial sweeteners, the most common of which in India are Equal and Sugar-Free Gold.
So is aspartame dangerous?

Over more than 40 years, aspartame has been one of the most widely studied and rigorously tested chemical additives in food, including for its possible links with cancer. More than 100 studies have found no evidence of harm caused by aspartame.

While doubts and concerns have continued to be raised by some critics and a few studies, there is a broad scientific consensus on the safety of aspartame for all groups of people except one — those suffering from phenylketonuria (PKU), a rare inherited disorder in which the patient does not have the enzyme that is needed to break down phenylalanine, one of the two amino acids in aspartame. Foods containing aspartame carry the warning “Not for phenylketonurics”.

The USFDA permitted the use of aspartame in food in 1981, and has reviewed the science of its safety five times since then, The Washington Post report said. Aspartame is also certified as safe for human consumption by the European Food Safety Authority (EFSA), national regulators in Japan, Australia, New Zealand, and Australia, and even the WHO’s JECFA. Around 100 countries around the world, including India, permit the use of aspartame.

The Reuters report noted that past IARC rulings have “raised concerns among consumers about their use, led to lawsuits, and pressured manufacturers to recreate recipes and swap to alternatives”. This, the report said, “has led to criticism that the IARC’s assessments can be confusing to the public.

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Ashes: Ben Duckett leads England fightback on crazy day at Lord’s

 Opener Ben Duckett hit 98 as England raced to 278-4 in an another high octane “Bazball” batting display to continue their Ashes fightback on day two of the second Lord’s test on Thursday after bowling Australia out for 416 on a memorable day’s action.

In the latest extraordinary display of modern-day test cricket, England enjoyed their best Ashes opening stand for 11 years and rattled to their total at almost five an over.

However, the counterpoint of their all-action approach meant they also gifted key wickets when well-set batsmen refused to back down in the face of Australia’s somewhat desperate short-pitched approach.

As the chaos mounted after tea, veteran Australian radio commentator Jim Maxwell described it as “the most bizarre hour’s cricket I’ve ever seen – this is madness at the home of cricket,” and few in the packed Lord’s grandstands would disagree.

England, so flat on Wednesday, began the day much more purposefully as Australia resumed on 339-5 with Steve Smith on 85, as Stuart Broad and Jimmy Anderson quickly removed Alex Carey and Mitchell Starc.

However, Smith, who on Wednesday became the fourth Australian to pass 9,000 runs, pressed on to claim his 32nd test century before finally departing for 110 via a superb catch by Duckett at second slip to give Josh Tongue his third wicket. Captain Pat Cummins, who batted superbly to bring Australia home in the first test, again looked assured to end unbeaten on 22 and, though he will be delighted with his team’s final tally, it represented something of a tail off from when they were seemingly cruising at 316-3 on Wednesday afternoon.

England set about their reply at their now customary speed and Duckett and Zak Crawley’s 91-run partnership was their best opening stand in the Ashes since Andrew Strauss and Alastair Cook put on 98 in Sydney in 2011.

Crawley looked particularly dominant until he was stumped for a run a ball 48 after what looked a pre-meditated advance to Nathan Lyon.

Ollie Pope came in and maintained the momentum as Australia’s attack struggled for any sort of penetration. He was looking untroubled with spaces all over the outfield but could not resist a Cameron Green bouncer and hooked it straight down the throat of Smith, one of three men placed on the leg side boundary for exactly that gift, to depart for 42.

Australia were celebrating even more loudly moments later when Joe Root, seemingly infected by the giddy excitement, was caught behind swinging wildly at the second ball he faced, only to be recalled after Green’s delivery was deemed a no ball.

Despite that escape, England continued to engage as Australia continued with their short ball/stacked leg side approach and Duckett was the next to pay the price, caught off a top-edged hook two short of a place on the Lord’s honours board.

Almost unbelievably Root followed soon after for 10 doing the same thing, well caught by Smith off Mitchell Starc, while Harry Brook was then dropped by Marnus Labuschagne at square leg, also swinging at a short ball.

It fell to captain Ben Stokes, of all people, to introduce a note of calm to proceedings during the final hour as the captain reminded his team mates that it is within the laws of the game to leave a bouncer.

He was unbeaten on 17 at the close with Brook on 45 and England trailing by 138.

Australia suffered a setback during the final session when off spinner Lyon, playing his 100th consecutive test, limped off in some distress with what looked like a calf injury which could leave Australia short of options in the fourth innings.

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